Pyroelectric Catalysis-Based “Nano-Lymphatic” Reduces Tumor Interstitial Pressure for Enhanced Penetration and Hydrodynamic Therapy

Because of the deficiency lymphatic reflux in tumor, retention tumor interstitial fluid causes aggravation pressure (TIP), which leads to unsatisfactory penetration nanomedicine. It is main inducement recurrence and metastasis. Herein, we design a pyroelectric catalysis-based Nano-lymphatic decrease TIP for enhanced treatments. realizes photothermal therapy decomposition under NIR-II laser irradiation after reaching reduces penetration. Simultaneously, reactive oxygen species generated during catalysis can further damage deep stem cells. The results indicate that relieves 52% TIP, leading penetration, effectively inhibits proliferation (93.75%) recurrence. Our finding presents rational strategy reduce by improved treatments, great significance drug delivery.